The XIII Maya Region is made up of five municipalities: Benemérito de las Américas, Catazajá, La Libertad, Marqués de Comillas and Palenque. It borders to the north with the state of Tabasco, to the south with Region XII Selva Lacandona and the Republic of Guatemala, to the east again with the Republic of Guatemala and to the west with Region XIV Tulijá Tseltal Chol.
The territory of the Maya Region occupies 5,981.51 km2, representing 8.1% of the state surface, being the fifth most significant region in the state. It is also part of the physiographic regions of the Gulf Coastal Plain, Eastern Mountains, and Northern Mountains; the relief of the land is formed mainly of hills and mountains, especially in the southwestern area.